CATEGORY: Artificial Intelligence, Big data, Clinical research, Real-World Data, Digital therapeutics SOURCE: Personalized Medicine Meets Artificial Intelligence. Springer, Cham. https://doi.org/10.1007/978-3-031-32614-1_6

The Role of Big Data and Artificial Intelligence in Clinical Research and Digital Therapeutics

Kyriazakos S., Pnevmatikakis A., op den Akker H., Kostopoulou K. (2023), In: Cesario, A., D’Oria, M., Auffray, C., Scambia, G. (eds) Abstract Healthcare is among the pioneering industries in the velocity of generation of big data, from the time that Electronic Health Records, Internet-of-Things, and electronic medical devices have been introduced. Researchers around the world are curating large volumes of data and applying Artificial Intelligent (AI) algorithms that give meaning to medical conditions, as well as prediction of clinical outcomes. The clinical research domain, which has been a laggard in digital transformation, is running today at high speed, utilizing electronic solutions that enable capturing of Real-World Data (RWD) in decentralized virtual clinical studies that aim to shorten the life cycle of drug development and the associated costs. At the same time, the domain of Digital Therapeutics (DTx) has been recently established, with various electronic solutions that process RWD to provide digital interventions that improve health-related endpoints. In this chapter, we will review how clinical research and DTx domains have been accelerated by the existence of Big data and AI algorithms and we will describe smart services that are expected to further boost the healthcare industry. Keywords: Artificial Intelligence, Big data, Clinical research, Real-World Data, Digital therapeutics

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