healthcare Archives - Healthentia

World Health Day

System — Fri, 07 Apr 2023 08:07:46 +0000

World Health Day is celebrated every year on April 7th to raise awareness about global health issues and to promote healthy living. This year’s theme is “Building a Fairer, Healthier World” and it highlights the need for equal access to healthcare for all people.

At Innovation Sprint, we believe that technology can play a crucial role in creating a fairer and healthier world. Our product Healthentia is a medical decision support software that is designed to monitor, detect, and offer virtual coaching services to patients based on Real-World Data gathered from clinical investigations or from those using it as a medical or well-being device.
Healthentia helps healthcare professionals make informed decisions about patient care by providing them with real-time insights into patient health. It also helps patients take charge of their health by providing them with personalized coaching and alerts to help them manage their conditions.

In addition to using technology to improve healthcare outcomes, it’s important to also promote active living as a key component of a healthy lifestyle. Active living refers to incorporating physical activity into your daily routine, whether it’s through exercise, sports, or other physical activities. We believe that promoting active living is essential to building a fairer and healthier world. Healthentia not only offers virtual coaching services to patients, but it also encourages them to adopt healthy behaviors such as regular physical activity. We recognize that physical activity can have a positive impact on a wide range of health outcomes, including reducing the risk of chronic diseases such as heart disease, diabetes, and cancer. By promoting active living, we can help individuals improve their overall health and well-being, which can in turn lead to a fairer and healthier world for all.

On this World Health Day, let’s remember the importance of staying active and make a commitment to incorporating physical activity into our daily routines.
Together, we can use technology and promote active living to build a fairer and healthier world for everyone.

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Healthentia at the edge: Healthentia services at the clinical data source

System — Thu, 24 Nov 2022 08:58:05 +0000

In many cases, clinical data cannot leave the premises of the healthcare organization that collects it. The comprehensive suite of Healthentia platform services for managing and processing data cannot address this issue. Instead, Innovation Sprint addresses the issue with specialized Healthentia edge services that facilitate data management and processing at the clinical data source. Thus, we increase the capabilities and resources at the hands of healthcare professionals, when they are working with data from different clinical sources, but also when mixed with real-world data from Healthentia. Specifically, the Healthentia edge services offer operational improvements in two important aspects, the provision of clinical data in the familiar Healthentia portal application, and the learning and use of composite clinical and behavioral models.

The Healthentia subject-level dashboard is enriched with clinical data using the Local Data Connector (LDC). LDCs are installed at hospital premises to facilitate the proper visualization of clinical data about a particular patient in the Healthentia subject-level dashboard, while the clinical data remains at the edge, without being ingested into the Healthentia platform. As a result, healthcare professionals have at their disposal a richer set of resources (composite clinical and real-world data analytics), improving their analytics experience by eliminating the need to use different tools and offering them more decision capabilities. LDCs are configured per hospital, to abstract the particularities of hospital information systems and create a message to be consumed by the browser, rendering the visualizations using metadata in the message along with the actual payload to be displayed.

The learning of composite clinical and behavioral models is also done at the edge (premises of the healthcare institution) utilizing edge installations of the Local Learning Services (LLS). The LLS facilitates model learning at the edge, employing the Innovation Sprint algorithms at the premises of the healthcare institutions, combining there the clinical and the Healthentia real-world data, formatting it into feature vectors suitable for learning models, and running the machine learning algorithms. The application of the resulting composite clinical and behavioral models enhances the healthcare professionals’ decision capabilities.

The use of the composite models is also done at the edge, employing the Local Inference Services (LIS) Healthentia edge service. LIS is an online service that also builds composite vectors, this time for online inference. The LIS then performs inference and transmits the inference results to the Healthentia platform.

The first version of the LDC and the LLS is being built in the context of the TERMINET project, as part of the TERMINET edge architecture. Stay tuned for news on their application in the SUPERO study that is now starting to enroll its first patients!

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Innovation Radar Prize 2022 – Disruptive Health

System — Tue, 18 Oct 2022 14:13:03 +0000

We are excited that Innovation Sprint is short-listed for the Innovation Radar Award on Disruptive Health, together with 9 other companies.

Since 2015 the European Commission has been awarding the annual Innovation Radar Prize to great EU-funded innovators, putting a spotlight on the high-potential innovations they are trying to get "out of the lab and into the market". Intelligence gathered by the Innovation Radar is used to identify innovators who can then compete for the prize.

The top innovation finalists are grouped into 3 categories of 10 each, out of a tremendous number of applications for the 2022 Innovation Radar Prize. The 3 categories are:

Disruptive Health
Purpose-driven & Green
Kickstarter

The Innovation Radar Prize 2022 includes voting from the public, which will assist the jury in their search for the best innovation of 2022.

Innovation Sprint is one of the 10 candidates for the Innovation Prize of Disruptive Health and we are looking forward to receiving your vote here.

Vote for Innovation Sprint

Why have we been selected as finalists?

Sofoklis Kyriazakos, CEO of Innovation Sprint, explains the reasons that brought Innovation Sprint to the final of the Innovation Radar Prize 2022.

Innovation is part of our company name, but foremost it is part of our DNA. Our purpose to improve health outcomes and outperform existing therapeutic care-paths using innovative technologies, has been an exciting and long journey from the day we started until where we are now commercializing our novel MedTech product in this highly regulated and challenging domain. Our product Healthentia, is a certified Software as Medical Device that uses best of breed of Internet, IoT, AI, and Big Data technologies together with clinical and regulatory knowledge to support healthcare professionals to monitor their patients, through digital clinical pathways addressing chronic conditions. Healthentia has been used so far in patient cohorts with cancer, heart failure, COPD, Covid-19, HIV, and other conditions. The clinical evidence that has been captured so far demonstrates increased adherence to treatment and Quality of Life, while we are currently running clinical studies, in which we monitor endpoints like mortality and rehospitalization. In Belgium, we are already at level 2 of the mHealthBELGIUM pyramid link, which paves the way towards reimbursement. We have market authorization for Europe and we have finalized the PreSub evaluation from FDA for 510(k) clearance. This journey was strongly influenced by our research activities, many of them performed under EC R&D projects, which contributed to the inclusion of key innovations in Healthentia and bringing the product to another level; a level that is backed up by science. We are committed to continuously improving Healthentia to disrupt health, by outperforming traditional treatments, thus contributing to Good Health and Wellbeing, one of the key sustainability goals of the UN. In this trajectory, we will continue to improve Healthentia in a way to address demanding market needs, regulatory challenges, while implementing our purpose to use innovative technologies to improve health outcomes and outperform existing therapeutic care paths.

What are the key innovations so far?

Aristodemos Pnevmatikakis, R&D Director of Innovation Sprint, explains Healthentia smart services and the role of EU co-funded projects in implementing them.

Healthentia is a secure big data platform for patient data, providing two applications to its two categories of end-users: a) Patients use the mobile app to facilitate the collection of their data and delivery of info and feedback, and b) healthcare professionals use the portal app to setup studies or programs to monitor their patients both as a cohort, or as individuals. Both applications are empowered by smart services: On the one hand, clinicians can handle patients in clusters and get insights from inference on models learnt on patients’ data. On the other hand, patients benefit from feedback on important attributes in their data, as these attributes are highlighted by explainable AI techniques.

EU co-funded projects have been playing a dual role in Healthentia. Looking back at our origins, the company started as the exploitation output of the eWALL project. Many more recent and ongoing projects have been instrumental in the implementation of our smart services. They allow us to run studies across Europe, increasing our volume and diversity of subjects, thus reducing the bias in the models we can learn from the collected data. They also facilitate early testing of our models in prototypes of our smart services. Last but not least, they facilitate our scientific output, by providing us with collaboration opportunities and funding for publications.

At Innovation Sprint we commit to providing patients and professionals with continuously improved smart services, aiming at helping the former improve the life of the latter.

How do we combine innovation with needs?

Konstantina Kostopoulou, Chief Product Officer of Innovation Sprint, explains how Healthentia has evolved into the solution it is today by combining innovation with the different stakeholder’s needs from the market.

Healthentia has been developed through participatory design and evaluation from stakeholders. Both the application for the patients and the portal for the clinicians are co-designed with patient focus groups and workshops with clinicians. In this product development journey, we have done user studies and interviewed patient focus groups after asking them to accomplish a set of tasks on the mobile app. They have evaluated the easiness and experience of using Healthentia. For similar tasks their valuable feedback is collected for feature optimizations. Regarding the clinician portal, regular sessions are taking place to collect feedback from clinicians to address their needs and optimize the assessment of a patients’ health state. We work together with clinicians from customizing their dashboards or enhance their patient record with selected clinical date from a hospital’s EMR. The Healthcare market include a great range of Stakeholders including but not limiting to, patients, caregivers, doctors, nurses, patient organizations, government, insurance companies, communities and pharmaceutical firms. Our collaborations within this market influence our product roadmap to meet the needs and expectations in this changing environment of digital Health.

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Healthentia enters the market of Patient Support Programs

System — Wed, 23 Feb 2022 08:19:43 +0000

Healthentia enters dynamically the market of Patient Support Programs, aiming to transform healthcare from doctor-driven to patient-driven care

Healthentia is a digital platform by Innovation Sprint that facilitates data capture in hybrid clinical trials and enables digital therapeutics as a certified medical device. It does so by offering a smartphone application for patients and a web portal for investigators and healthcare professionals to securely access smart services and insights. Healthentia empowers patients in clinical studies and gives them an active role in taking trial actions, rather than bringing them to the trial sites. Healthentia is used by Top5 Pharma and hospitals and operates under the strict regulatory framework of Good Clinical Practice.

In 2021, Healthentia medical device entered the market of Patient Support Programs (PSP) as a decision support software intended to monitor, detect and predict outcomes, offer virtual coaching services and generate automatic alerts regarding events, based on Real World Data gathered from patients. Healthentia PSPs are offered jointly with healthcare organizations and pharmaceutical companies and follow co-development, participatory-design, and patient-centric approaches. In 2022 Healthentia is expected to collect evidence that will create clinical claims on its efficacy as a therapeutic device.

What is a Patient Support Program (PSP)?

A PSP provides an integrated approach to remote care with digital services to support patients during medical treatments. Today, digital platforms for remote patient monitoring are the technical infrastructure of PSPs, offering notifications services for therapy, functionalities for booking hospital visits, and questionnaires to be filled in. More advanced solutions enable the capturing of data from wearable and other medical devices, as well as teleconsultation and virtual coaching as a therapy.

How can a digital platform transform healthcare?

If we can better educate patients and enable them to share data between the periodic visits, we can improve their engagement in daily self-management of their health and the interactions with the care team by personalizing the care plan, making sure they understand why adherence matters, and providing ways to individually achieve it, patients will increase their understanding of care plan, medication regimen and their engagement with care plan activities and confidence in disease management. By using the PSP app and staying connected with the care team, patients will be able to stay engaged in remotely reporting their clinical metrics, wellbeing, and adherence in-between visits. Finally, by having new remote monitoring data, care plans can be adjusted at the follow-up visits, and situations that require clinical attention can be identified earlier.

Do you want to know more? Please visit www.healthentia.com

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Healthentia Care4Covid solution

System — Thu, 06 May 2021 10:22:10 +0000

One more project is added to the Innovation Sprint’s portfolio, the Care4Covid, which is part of the COVID-X Programme.

The COVID-X Programme aims to accelerate companies with Medical Devices that have a track record with Covid-X applications and support them to introduce solutions of strong impact to the market.

Since March 2020, Innovation Sprint helps Hospitals and other Healthcare Organizations to improve their Covid-19 resilience and response by managing Covid-19 related symptoms of patients and health workers from remote and providing targeted support and care guidelines to them.

The Care4Covid solution is a remote care and remote support solution, yet it directly boosts the business continuity and operational efficiency of healthcare organizations as well. The solution was initially developed in March 2020, following the pandemic outbreak. It was developed as pivot of the Healthentia eClinical platform, which already provided symptom-tracking functionalities and used by Top5 Pharma for clinical studies. Innovation Sprint adapted its Healthentia Symptom tracker towards tracking Covid-19 symptoms and managing patients-provided Covid-19 information.

During the past months, the solution has evolved to provide remote management and support for healthcare workers, in terms of their Covid-19 related status and symptoms. As of today, Healthentia is used in several Covid-19 related clinical studies and recently it has launched its Vax version to support tracking of the vaccination programme.

Therefore, the problems that are solved by the use of Healthentia are related to:

Preventive actions by clustering patients & healthy individuals into risk categories
Remote monitoring and supporting of patients
Execute workflows and clinical pathways to Covid-19 positive cases
Business Continuity in large organizations
Follow-up of vaccination programme

Care4Covid is leveraging the existing infrastructure of Healthentia for reporting, tracking, and analysing the symptoms of the patients, Innovation Sprint has developed a data-driven infrastructure that provides targeted care recommendations to healthcare workers and Covid-19 patients using the Healthentia Covid-19 app.

The novelty of the solution, therefore, lies in the Covid-19 profiling of different patients’ phenotypes and the provision of personalized care support and recommendations to them. Through the participation of Innovation Sprint in the COVID-X Programme, it will be feasible to extend the functionalities of the solution through the COVID-X sandbox and the accumulated knowledge of the clinical partners available, thus creating a new version of the solution, namely Healthentia Care4Covid.

*Healthentia application is a certified Class I Medical Device.

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Healthentia is now a Class I Medical Device

System — Wed, 27 May 2020 14:52:49 +0000

Sofoklis Kyriazakos, CEO of Innovation Sprint, analyzes his thoughts on our strategic plan to certify Healthentia app as a Class I Medical Device. Below you can find the original blog post he wrote on medium platform "Pushing the boundaries of Clinical Research to support eHealth services: a promising Paradox to break down the Silos".

Coming from a technological background in the Life Sciences domain, it wasn’t clear to me during the first years, which are the boundaries of healthcare and clinical research. I could see overlapping areas between these sectors and it was difficult to understand why they are practically far apart. In this blog post, I am presenting our efforts and strategic decisions to break down the silos of these two sectors, thus making it possible to provide validated personalized medical services.

In my own words, clinical research is a science using clinical trials to research new drugs and interventions (so called “interventional” or to extract valuable information from “standard clinical practice” in a retrospective or prospective manner (so called “observational”). Subjects in clinical studies are mostly patient volunteers that take the treatment and provide their outcomes for evaluation, under a strict, ethically cleared, protocol. The healthcare sector is easier to understand, as it includes medical services (e.g. treatments) and medical devices for health monitoring. Both sectors have as common characteristics: a) they aim on a better health; b) they are strongly regulated; and c) they account for a significant percentage of the GDP.

From the moment Internet started to penetrate to the masses, many research and industrial activities around the world were initiated around the so-called eHealth sector. Unfortunately, a large majority of them fail, because their business model is not viable, or they lack validation. The healthcare sector has the peculiarity in many countries to be different. In particular, most of the European Healthcare Systems are public and provided by the Payers. If your solution is not subject to reimbursement, then you need to get your money from the patient directly. Is this viable? Can a European patient pay for your eHealth service -let’s say- 50€ a year? Even though we know this model from Netflix, Spotify, iCloud, etc, this cannot apply to eHealth services adding up to an already expensive tax paid public healthcare service. To sum up, on the one hand side, Clinical solutions are not considered as medical services; and on the other hand side, medical solutions are most of the times not clinically validated (because getting a proof-of-concept, clinically valid with regulatory grade certification is a risky painfully costly business: ask your proxy Pharma CEO how much he spent for the last market access authorization for a new drug…). Isn’t that weird?

In previous posts, I have indicated that the clinical domain is lagging behind technology and it has only recently started to make small steps towards digital transformation. This is linked with several services and solutions, like ePRO/eCOA (electronic Patient Reported Outcomes / electronic Clinical Outcome Assessments) and many more. All these solutions are meant to collect data from patients — subjects of clinical studies that can be used to verify the clinical endpoints of a study and get a drug approved for marketing. These solutions however, capture the subjective data, i.e. data provided by the patient about his/her QoL, pain, comfort, etc. All the missing data (mainly lifestyle related) is not considered, despite the strong evidence that it is significantly impacting everyday life. Healthentia is among the few ePRO/eCOA solutions that capture the missing data and we innovate by considering this data in our proprietary deep phenotyping Machine Learning processes to derive behavioral/lifestyle models that can enable smart services and outline actionable and reliable predictive models.

At the moment we started designing our Deep Phenotyping processes (pardon us, we continue pushing the boundaries of commonly accepted definitions here: by deep phenotyping we intend characterizing in depth, and then modeling, the lifestyle patterns of any individual, to a level of granularity which is comparable to that used to define and then model molecular behaviours in cellular pathways), we realized that the derived smart services could be used for in-silico trials, but also for virtual coaching services, for which we have a long history and successes pedigree. The happiness was soon followed by concerns coming from the Medical Device Regulation (MDR) and the European Medical Device Vigilance System (MEDDEV), which are introduced in Europe in order to protect human subjects. I like to compare MDR with GDPR, as they come from the same source, they are made to protect citizens, they cost a lot to implement and sometimes “spread the fear” sometimes. At that time we enrolled to the MedTech accelerator from Lifetech.Brussels, which helped us to get a better understanding of the opportunities and threats. From that moment, it became a strategic decision to see how our ePRO/eCOA solution could go through this process and become a Medical Device. We started with Class I to cover the AI elements for decisions-making and virtual coaching, because we strongly believe that we should establish the link between clinical research and health in a personalized manner.

In our talks with my partner and co-founder Alfredo about the link between clinical research and health, it was clear that the concept was backed up by the needs coming from the growing understanding of the huge impact a systematic approach to Medicine with more and more evidence built on the modeling of greater and greater information (the so called Medical Big Data) was having in shaping modern Personalised Medicine. Under this “Systems’ Medicine” perspective, in fact, the all of the individual information amounts to significance, especially lifestyle behavior that can easily cluster phenotypes as impacting the evolution of a disease and the outcome of any given treatment to cure it. In this setting, smartly gathering longitudinal objective and subjective RWD and extracting from them actionable models to predict the outcome of any given treatment ads “depth” to the personalisation paradigm adding up measureble predictive value via robust participation support (see: https://pubmed.ncbi.nlm.nih.gov/24641231/).

Unlike most eHealth solutions out there, Healthentia is both clinically validated and a certified Class I Medical Device and therefore, a good candidate for digital therapeutics 2.0. This opens the trajectory that similar smart services can in the future be authorized for prescription by the Competent Authorities and reimbursed by the Payers, offering personalized healthcare services, based on the anonymous processing of lifestyle observations from the clinical processes, by robustly respecting all privacy and regulatory contexts. In short, Pharma will be able to create better drugs and interventions of higher efficacy, while these outcomes can be used to drive smart AI services for the healthcare sector. Isn’t this a promising paradox?

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Get a Healthentia Demo @DIA Europe 2019

System — Tue, 22 Jan 2019 12:47:49 +0000

We are delighted to kick off the year with such a big event like DIA Europe .We participate with our eclinical solution, Healthentia.

About DIA Europe

DIA Europe is more than just a traditional meeting. As members say “there is something special about DIA Europe”: It’s a chance to learn, engage, and grow as a professional in healthcare. Thought leaders across all disciplines unite together in a neutral forum to discuss current issues, with the goal of uncovering new ways of working and new solutions for patients. It’s a chance to learn, engage, and grow as a healthcare professional alongside thousands of cross-functional collaborative leaders.

After a momentous showing in Basel in 2018, DIA Europe headed to Vienna.

The event will take place at the Austria Center Vienna. Surrounded by contemporary architecture, just 7 minutes from the city centre and a few minutes’ walk from the Danube and the Donaupark, Austria Center Vienna is Austria’s largest conference center.

Healthentia Demo

Together with our partners find us at booths of CrosNT and Arithmos Life Sciences where we will be demonstrating Healthentia live.

Check out the official Site of DIA

Come look for us, February 5-7 in Vienna

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